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Centre d'Immunologie et des Maladies Infectieuses
UPMC UMRS CR7 - Inserm U1135 - CNRS ERL 8255

Séminaire 20/12/17 - Stephan von Gunten (Univ. Bern)

13h, Salle 616 Bât "91"

Stephan von gunten (Inst. Pharmacology, Un. Bern, CH)

Title : "Therapeutic immunoglobulins: insights on repertoires and mechanisms"

 Invitant : G. Gorochov

Our laboratory is interested in molecular mechanisms that control inflammation and cancer.

Intravenous immunoglobulin (IVIG) preparations contain the antibody repertoire of the donor population (up to 50’000 individuals) and both Fc-mediated and subfractions of specific antibodies, also referred to as specific IVIG, are thought to contribute to the anti-inflammatory effects of this pluripotent drug. IVIG-induced regulation of activated neutrophil survival in humans is exclusively a function of specific antibodies against Fas, Siglec-8 and -9 receptors and is not Fc-mediated. Further, analysis using glycan array technology, we noticed a modular organization and universal architecture of the carbohydrate-specific IgG repertoire among different donor populations. This architecture is highly disturbed in patients with primary antibody deficiencies (PAD), surprisingly to a similar degree across different PAD entities, suggesting a common algorithm of immune systems failure (ISF) in these patients.

The group leader Dr. S. von Gunten is a participating investigator at the Consortium of Functional Glycomics (www.functionalglycomics.org), funded by the US National Institutes of Health (NIH), that aims at defining paradigms by which protein-carbohydrate interactions mediate cell communication. Our group has collaborations with scientists and clinicians from many international and local academic institutions, companies and hospitals.

18/12/17

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