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Centre d'Immunologie et des Maladies Infectieuses
UPMC UMRS CR7 - Inserm U1135 - CNRS ERL 8255

Séminaire 06/12/17 - John Anderson (Karolinska Inst.)

13h, Salle 616 Bât "91"

John Anderson (Dept. Med. Solna, Karolinska Inst., Stockholm, Se)

Title : FOXP3 and CTLA-4: how isoforms regulate immunological tolerance

 Invitant : G. Gorochov

The immune system is the body's defense against infectious organisms. Furthermore, the immune system contributes to the progression of most of today’s non-communicable diseases including cancer and cardiovascular diseases. We study CD4+FOXP3+ regulatory T (Treg) cells that suppress immune activation and modulate the outcome of both inflammatory diseases and cancer. Treg cells depend on the transcription factor FOXP3 and mutations in the FOXP3 gene leads to a fatal lymphoproliferative disorder known as immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX). Treg cells have been extensively studied, however, two aspects of Treg cell biology remain unresolved. First, the transcription factor FOXP3 is required for Treg cell function, but the regulation and function of FOXP3 isoforms remain almost entirely unknown. Second, Treg cells inhibit immune responses by suppressing dendritic cells (DCs), but the exact mechanisms that Treg cells utilize remain controversial. The ultimate objective of our research program is to find new possibilities to control immune responses in humans by targeting Treg cells.



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