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Centre d'Immunologie et des Maladies Infectieuses
UPMC UMRS CR7 - Inserm U1135 - CNRS ERL 8255

The Insectarium

To develop and strengthen its research on Malaria, CIMI-Paris is equipped with an insectarium dedicated for mosquito breeding and maintaining the colonies of Anopheles stephensi, a vector mosquito that supports the development of sexual stages of different Plasmodium species for the production of sporozoites, an invasive form of the parasites contained in salivary glands of the mosquito. The insectarium thus ensures the production of Plasmodium sporozoites essential for teams working on the pre-erythrocytic stages of malaria parasites, the earliest phases of Plasmodium infection. The goal is to understand how sporozoites enter liver cells and to dissect the liver stage development of the different species, in order to identify new liver stage vaccine and drug targets. The CIMI teams possess the know-how in the production of sporozoites from rodent, simian and human malaria parasites (from the rearing of Anopheles mosquitoes in the CIMI insectary, their routine infection with infected mice or through standard membrane feeding with simian- or human-infected blood samples, to the purification of sporozoites) and the study of the development of these parasites either in vivo in classical rodent models, or in innovative models of liver-humanized mice, as well as in robust in vitro culture systems of fresh or cryopreserved hepatocytes. The insectarium is open to research teams other than Cimi-Paris.

18/10/17

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Contact

cimi-paris @ upmc.fr