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Centre d'Immunologie et des Maladies Infectieuses
UPMC UMRS CR7 - Inserm U1135 - CNRS ERL 8255

Immunity and Vaccination - Béhazine COMBADIERE

Team members

Team Research Program

Our team is trying to improve current methods of vaccination by the development of new vaccine strategies.
We have a special interest in skin vaccination, that is richly populated by innate immune cells, which are important for the induction and polarization of the adaptive immune response.

To improve vaccination stratégies, we seek to understand all the cellular and molecular mechanisms involved in the immune response to vaccines and against viral infections. Our project integrates basic research, and the transfer of knowledge to clinical trials in humans.

These researches are performed within the center and in collaboration with international teams. The major achievement of the team is the development of a needle-free vaccination method by targeting the hair follicles, for which proof of concept has been provided by numerous clinical trials in humans.

Team technical expertise

Human skin explants(SkinSe platform), Mice models, Multi-parametric flow cytometry, Humanized mice for immune systems, Immunohistology, Systems biology, Proteomics, Transcriptomic.

Main achievements

Transcutaneous immunization.

External funding (current)

  • H2020 UE (2016-2020): EAVY2020 (European AIDS Vaccine Initiative)
  • ANR (2014-2019) : ASIO (Analyse Omics du système immunologique du tissu cutané)

Publications (PDF):

(2017 - 2016 - 2015 - 2014 - 2013)

20/11/17

Traductions :

Contact

cimi-paris @ upmc.fr

To see

Key words

Vaccination, Hair follicular targeting, Innate immunity, T cell response, Skin immune cells, Humanized mice, Multi-parametric immune response analysis

Fields of application

Vaccinology