Immunity and Vaccination - Béhazine COMBADIERE
Team Research Program
Our team is trying to improve current methods of vaccination by the development of new vaccine strategies.
We have a special interest in skin vaccination, that is richly populated by innate immune cells, which are important for the induction and polarization of the adaptive immune response.
To improve vaccination stratégies, we seek to understand all the cellular and molecular mechanisms involved in the immune response to vaccines and against viral infections. Our project integrates basic research, and the transfer of knowledge to clinical trials in humans.
These researches are performed within the center and in collaboration with international teams. The major achievement of the team is the development of a needle-free vaccination method by targeting the hair follicles, for which proof of concept has been provided by numerous clinical trials in humans.
Team technical expertise
Human skin explants(SkinSe platform), Mice models, Multi-parametric flow
cytometry, Humanized mice for immune systems, Immunohistology, Systems biology, Proteomics, Transcriptomic.
Main achievements
Transcutaneous immunization.
External funding (current)
- H2020 UE (2016-2020): EAVY2020 (European AIDS Vaccine Initiative)
- ANR (2014-2019) : ASIO (Analyse Omics du système immunologique du tissu cutané)