Anti-viral and Vaccinal Immunity and Immunogenetics - Brigitte AUTRAN
Team research program
Our team studies celular immunity to vaccines to viruses and develops/evaluates immune-based interventions and therapeutic vaccines, with large access to infectious diseases and immunocompromised patients. The approaches developed are mainly oriented on studies of:
- The immune control mechanisms of viral HIV reservoirs (transcriptional control mechanisms of CD4 cells, including those involving the transcriptional repressor Blimp-1 in B cells).
- Immunity and anti-viral vaccine and the development of HIV vaccines
- Regulation of the mechanisms during infection by the virus oncogenes HHV-8
- Immunosuppression and Cancer
- Inflammatory diseases and comorbidities of HIV infection
- The immunogenetics of HIV and Hepatitis C Virus: Study of the association between human genetic polymorphism and progression of chronic viral infections due to HIV and HCV
Technical expertise
Molecular and serologic diagnosis of herpesvirus and HBV infections
Molecular biology techniques (PCR, RT-PCR, sequencing, cloning, expression, computer analysis) applied to the study of viral genomes and transcripts
Phenotypic and genetic assays for the determination of susceptibility or resistance to antivirals
Transgenic mouse models of HBV infection
Main achievements
- Demonstration of a long-term immune memory to some vaccines and the impact of immune-suppression and senescence (JEM 2004, Vaccine 2009, JCI 2010)
- Characterization of immunity to influenza-vaccines in immunocompromised patients (Arth.Rheum 2010, AIDS 2010, Vaccine 2012, 2014, Amer. Rev. Crit. Care Med 2014, JCI 2014)
- Evaluation of the clinical efficacy of anti-HIV therapeutic vaccines (Science 2000, 2004, Vaccine 2005, JID 2005,09, AIDS 2009,11, Sc. Transl. Med. 2013)
External funding (current)
At academic level:
ANRS
Sidaction
PHRC
From industry:
Janssen
BMS